English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming

Daujat, S., Weiss, T., Mohn, F., Lange, U. C., Ziegler-Birling, C., Zeissler, U., et al. (2009). H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming. Nature Structural & Molecular Biology, 16(7), 777-781. doi:10.1038/nsmb.1629.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D5C-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D5D-7
Genre: Journal Article
Alternative Title : Nature Struct & Mol Biol

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Daujat, Sylvain, Author
Weiss, Thomas, Author
Mohn, Fabio, Author
Lange, Ulrike C., Author
Ziegler-Birling, Céline, Author
Zeissler, Ulrike, Author
Lappe, Michael1, Author              
Schübeler, Dirk, Author
Torres-Padilla, Maria-Elena, Author
Schneider, Robert, Author
Affiliations:
1Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

Content

show
hide
Free keywords: -
 Abstract: Histone modifications are central to the regulation of all DNA-dependent processes. Lys64 of histone H3 (H3K64) lies within the globular domain at a structurally important position. We identify trimethylation of H3K64 (H3K64me3) as a modification that is enriched at pericentric heterochromatin and associated with repeat sequences and transcriptionally inactive genomic regions. We show that this new mark is dynamic during the two main epigenetic reprogramming events in mammals. In primordial germ cells, H3K64me3 is present at the time of specification, but it disappears transiently during reprogramming. In early mouse embryos, it is inherited exclusively maternally; subsequently, the modification is rapidly removed, suggesting an important role for H3K64me3 turnover in development. Taken together, our findings establish H3K64me3 as a previously uncharacterized histone modification that is preferentially localized to repressive chromatin. We hypothesize that H3K64me3 helps to 'secure' nucleosomes, and perhaps the surrounding chromatin, in an appropriately repressed state during development.

Details

show
hide
Language(s): eng - English
 Dates: 2009-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Structural & Molecular Biology
  Alternative Title : Nature Struct & Mol Biol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 16 (7) Sequence Number: - Start / End Page: 777 - 781 Identifier: ISSN: 1545-9993