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  CA8 Mutations Cause a Novel Syndrome Characterized by Ataxia and Mild Mental Retardation with Predisposition to Quadrupedal Gait

Türkmen, S., Guo, G., Garshasbi, M., Hoffmann, K., Alshalah, A. J., Mischung, C., et al. (2009). CA8 Mutations Cause a Novel Syndrome Characterized by Ataxia and Mild Mental Retardation with Predisposition to Quadrupedal Gait. PLoS Genetics, 5, e1000487-e1000487. doi:10.1371/journal.pgen.1000487.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D89-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D8A-1
Genre: Journal Article

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 Creators:
Türkmen, Seval1, Author              
Guo, Gao, Author
Garshasbi, Masoud1, Author              
Hoffmann, Katrin2, Author              
Alshalah, Amjad J., Author
Mischung, Claudia, Author
Kuss, Andreas3, Author              
Humphrey, Nicholas, Author
Mundlos, Stefan2, Author              
Robinson, Peter N.2, Author              
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
3Familial Cognitive Disorders (Luciana Musante), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479644              

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 Abstract: We describe a consanguineous Iraqi family in which affected siblings had mild mental retardation and congenital ataxia characterized by quadrupedal gait. Genome-wide linkage analysis identified a 5.8 Mb interval on chromosome 8q with shared homozygosity among the affected persons. Sequencing of genes contained in the interval revealed a homozygous mutation, S100P, in carbonic anhydrase related protein 8 (CA8), which is highly expressed in cerebellar Purkinje cells and influences inositol triphosphate (ITP) binding to its receptor ITPR1 on the endoplasmatic reticulum and thereby modulates calcium signaling. We demonstrate that the mutation S100P is associated with proteasome-mediated degradation, and thus presumably represents a null mutation comparable to the Ca8 mutation underlying the previously described waddles mouse, which exhibits ataxia and appendicular dystonia. CA8 thus represents the third locus that has been associated with quadrupedal gait in humans, in addition to the VLDLR locus and a locus at chromosome 17p. Our findings underline the importance of ITP-mediated signaling in cerebellar function and provide suggestive evidence that congenital ataxia paired with cerebral dysfunction may, together with unknown contextual factors during development, predispose to quadrupedal gait in humans.

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Language(s): eng - English
 Dates: 2009-05-22
 Publication Status: Published in print
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Title: PLoS Genetics
Source Genre: Journal
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Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: e1000487 - e1000487 Identifier: ISSN: 1553-7390)