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  Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation

Witte, F., Dokas, J., Neuendorf, F., Mundlos, S., & Stricker, S. (2009). Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expression Patterns, 9(4), 215-223. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6W8W-4VC7DXP-1-1F&_cdi=6665&_user=127795&_pii=S1567133X08001439&_orig=browse&_coverDate=04%2F30%2F2009&_sk=999909995&view=c&wchp=dGLbVlW-zSkzS&md5=ee8d4fcc41398313229ff0817c26e751&ie=/sdarticle.pdf.

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 Creators:
Witte, Florian1, Author              
Dokas, Janine2, Author
Neuendorf, Franziska2, Author
Mundlos, Stefan3, Author              
Stricker, Sigmar3, Author              
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Max Planck Society, ou_persistent13              
3Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Limb development; Chondrogenesis; Growth plate; Wnt; Sfrp; Frzb; Dkk; Wisp; Wif1
 Abstract: Wnt signalling plays important roles in patterning and outgrowth of the vertebrate limb. Different mutations in Wnt genes, their antagonists or (co-)receptors result in patterning and outgrowth defects as well as chondrocyte and bone phenotypes in mouse and human. Understanding Wnt activity during mouse limb development and chondrogenesis requires a temporal and spatial overview of Wnt signalling key factor expression. Here we present a comparative expression analysis of all 19 Wnt genes and their major secreted antagonists of the Dickkopf (Dkk), Wisp and the secreted frizzled related protein (Sfrp) families during mouse limb development. Our study reveals new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. We also identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5, Wisp1 as well as Dkk2 and Dkk3. We provide a full expression pattern for Wif1 in limb development, for which no limb expression had been documented so far.

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Language(s): eng - English
 Dates: 2009-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Gene Expression Patterns
Source Genre: Journal
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Pages: - Volume / Issue: 9 (4) Sequence Number: - Start / End Page: 215 - 223 Identifier: ISSN: 1567-133X