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  Expression profile and transcription factor binding site exploration of imprinted genes in human and mouse.

Steinhoff, C., Paulsen, M., Kielbasa, S., Walter, J., & Vingron, M. (2009). Expression profile and transcription factor binding site exploration of imprinted genes in human and mouse. BMC Genomics, 10, e144-e144. doi:10.1186/1471-2164-10-144.

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Genre: Journal Article
Alternative Title : BMC Genomics

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Steinhoff,, Christine1, Author
Paulsen, Martina, Author
Kielbasa, Szymon1, Author
Walter, Jörn2, Author              
Vingron, Martin3, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
3Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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 Abstract: Background In mammals, imprinted genes are regulated by an epigenetic mechanism that results in parental origin-specific expression. Though allele-specific regulation of imprinted genes has been studied for several individual genes in detail, little is known about their overall tissue-specific expression patterns and interspecies conservation of expression. Results We performed a computational analysis of microarray expression data of imprinted genes in human and mouse placentae and in a variety of adult tissues. For mouse, early embryonic stages were also included. The analysis reveals that imprinted genes are expressed in a broad spectrum of tissues for both species. Overall, the relative tissue-specific expression levels of orthologous imprinted genes in human and mouse are not highly correlated. However, in both species distinctive expression profiles are found in tissues of the endocrine pathways such as adrenal gland, pituitary, pancreas as well as placenta. In mouse, the placental and embryonic expression patterns of imprinted genes are highly similar. Transcription factor binding site (TFBS) prediction reveals correlation of tissue-specific expression patterns and the presence of distinct TFBS signatures in the upstream region of human imprinted genes. Conclusion Imprinted genes are broadly expressed pre- and postnatally and do not exhibit a distinct overall expression pattern when compared to non-imprinted genes. The relative expression of most orthologous gene pairs varies significantly between human and mouse suggesting rapid species-specific changes in gene regulation. Distinct expression profiles of imprinted genes are confined to certain human and mouse hormone producing tissues, and placentae. In contrast to the overall variability, distinct expression profiles and enriched TFBS signatures are found in human and mouse endocrine tissues and placentae. This points towards an important role played by imprinted gene regulation in these tissues.

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Language(s): eng - English
 Dates: 2009-03-31
 Publication Status: Published in print
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Title: BMC Genomics
  Alternative Title : BMC Genomics
Source Genre: Journal
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Pages: - Volume / Issue: 10 Sequence Number: - Start / End Page: e144 - e144 Identifier: ISSN: 1471-2164