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  Transcription networks in heart development and disease with detailed analysis of TBX20 and DPF3.

Tönjes, M. (2009). Transcription networks in heart development and disease with detailed analysis of TBX20 and DPF3. PhD Thesis, Freien Universität Berlin, Berlin.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7E02-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7E03-3
Genre: Thesis

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 Creators:
Tönjes, Martje1, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Language(s): eng - English
 Dates: 2009-03
 Publication Status: Accepted / In Press
 Pages: 111
 Publishing info: Berlin : Freien Universität Berlin
 Table of Contents: 1 Introduction
1.1 Heart development 1
1.2 Essential factors of transcriptional regulation during cardiogenesis
1.2.1 Signaling molecules and transcription factors 4
1.2.2 Histone modifications and chromatin remodeling 7
1.3 Congenital heart disease 11
2 Aim of the project 16
3 Prediction of cardiac transcription networks based on molecular data and
complex phenotypes
3.1 Synopsis 17
3.2 Experimental contributions 21
Published in Molecular BioSystems; Journal’s page numbering 589-598
DOI:10.1039/b800207j
4 The cardiac transcription network driven by Gata4, Mef2a, Nkx2.5 and Srf
and epigenetic marks
4.1 Synopsis 25
4.2 Experimental contributions 27
4.3 Manuscript 28
In preparation; page numbering 1-20
4.4 Supplemental material 48
5 Characterization of TBX20 in human hearts and its regulation by TFAP2
5.1 Synopsis 73
5.2 Experimental contributions 75
Published in Journal of Cellular Biochemistry; Journal’s page numbering 1022-1033
DOI: 10.1002/jcb.21686
6 Regulation of muscle development by DPF3, a novel histone acetylation and
methylation reader of the BAF chromatin remodeling complex
6.1 Synopsis 79
6.2 Experimental contributions 81
Published in Genes & Development; Journal’s page numbering 2370-2384
DOI: 10.1101/gad.471408
7 Discussion
7.1 Prediction of cardiac transcription networks 83
7.2 Characterization of the transcription factor TBX20 86
7.3 The novel epigenetic regulator DPF3 88
8 References 91
9 Appendix
9.1 Summary 101
9.2 Zusammenfassung 102
9.3 Curriculum Vitae 105
9.4 Acknowledgements 109
9.5 Selbständigkeitserklärung 111
 Rev. Type: -
 Identifiers: eDoc: 444378
 Degree: PhD

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