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  Methylation and deamination of CpGs generate p53-binding sites on a genomic scale.

Zemojtel, T., Kielbasa, S. M., Arndt, P. F., Chung, H.-R., & Vingron, M. (2009). Methylation and deamination of CpGs generate p53-binding sites on a genomic scale. Trends in Genetics, 25(2), 63-66. doi:10.1016/j.tig.2008.11.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7E26-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7E27-4
Genre: Journal Article
Alternative Title : TiG

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 Creators:
Zemojtel, Tomasz1, Author              
Kielbasa, Szymon M.1, Author              
Arndt, Peter F.2, Author              
Chung, Ho-Ryun3, Author              
Vingron, Martin4, Author              
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Evolutionary Genomics (Peter Arndt), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479638              
3Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479658              
4Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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 Abstract: The formation of transcription-factor-binding sites is an important evolutionary process. Here, we show that methylation and deamination of CpG dinucleotides generate in vivo p53-binding sites in numerous Alu elements and in non-repetitive DNA in a species-specific manner. In light of this, we propose that the deamination of methylated CpGs constitutes a universal mechanism for de novo generation of various transcription-factor-binding sites in Alus.

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Language(s): eng - English
 Dates: 2009-02-01
 Publication Status: Published in print
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Title: Trends in Genetics
  Alternative Title : TiG
Source Genre: Journal
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Pages: - Volume / Issue: 25 (2) Sequence Number: - Start / End Page: 63 - 66 Identifier: ISSN: 0168-9525