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  Essential role of glucose transporter GLUT3 for post-implantation embryonic development

Schmidt, S., Hommel, A., Gawlik, V., Augustin, R., Junicke, N., Florian, S., et al. (2009). Essential role of glucose transporter GLUT3 for post-implantation embryonic development. Journal of Endocrinology, 200(1), 23-33. doi:10.1677/JOE-08-0262.

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Genre: Journal Article
Alternative Title : J Endocrinol

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 Creators:
Schmidt, S., Author
Hommel, A., Author
Gawlik, V., Author
Augustin, R., Author
Junicke, N., Author
Florian, S., Author
Richter, M., Author
Walther, D. J.1, Author              
Montag, D., Author
Joost, H.-G., Author
Schürmann, A., Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: Deletion of glucose transporter gene Slc2a3 (GLUT3) has previously been reported to result in embryonic lethality. Here, we define the exact time point of growth arrest and subsequent death of the embryo. Slc2a3–/– morulae and blastocysts developed normally, implanted in vivo, and formed egg-cylinder-stage embryos that appeared normal until day 6.0. At day 6.5, apoptosis was detected in the ectodermal cells of Slc2a3–/– embryos resulting in severe disorganization and growth retardation at day 7.5 and complete loss of embryos at day 12.5. GLUT3 was detected in placental cone, in the visceral ectoderm and in the mesoderm of 7.5-day-old wild-type embryos. Our data indicate that GLUT3 is essential for the development of early post-implanted embryos.

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Language(s): eng - English
 Dates: 2009-01
 Publication Status: Published in print
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Title: Journal of Endocrinology
  Alternative Title : J Endocrinol
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 200 (1) Sequence Number: - Start / End Page: 23 - 33 Identifier: ISSN: 0022-0795