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  Stemming cancer : functional genomics of cancer stem cells in solid tumors

Regenbrecht, C. R. A., Lehrach, H., & Adjaye, J. (2008). Stemming cancer: functional genomics of cancer stem cells in solid tumors. Stem Cell Reviews, 4(4), 319-328. doi:10.1007/s12015-008-9034-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7EB3-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7EB4-8
Genre: Journal Article
Alternative Title : Stem Cell Rev

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 Creators:
Regenbrecht, Christian R. A.1, Author              
Lehrach, Hans2, Author              
Adjaye, James1, Author              
Affiliations:
1Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479654              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: Cancer stem cell, Functional genomics, Genome-wide expression-profiling, Cell of origin, Tumor hierarchy, Self-renewal, Pathway-analysis
 Abstract: Cancer stem cells (CSCs) were discovered about 15 years ago in hematopoietic cancers. Subsequently, cancer stem cells were discovered in various solid tumors. Based on parallels with normal stem cells, a developmental process of cancer stem cells follows paths of organized, hierarchical structure of cells with different degrees of maturity. While some investigators have reported particular markers as identification of cancer stem cells, these markers require further research. In this review, we focus on the functional genomics of cancer stem cells. Functional genomics provides useful information on the signaling pathways which are consecutively activated or inactivated amongst those cells. This information is of particular importance for cancer research and clinical treatment in many respects. (1) Understanding of self-renewal mechanisms crucial to tumor growth. (2) Allow the identification of new, more specific marker for CSCs, and (3) pathways that are suitable as future targets for anti-cancer drugs. This is of particular importance, because today’s chemotherapy targets the proliferating cancer cells sparing the relatively slow dividing cancer stem cells. The first step on this long road therefore is to analyze genome-wide expression-profiles within the same type of cancer and then between different types of cancer, encircling those target genes and pathways, which are specific to these cells.

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Language(s): eng - English
 Dates: 2008-11-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: Stem Cell Reviews
  Alternative Title : Stem Cell Rev
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 4 (4) Sequence Number: - Start / End Page: 319 - 328 Identifier: ISSN: 1550-8943