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  ConsensusPathDB—a database for integrating human functional interaction networks

Kamburov, A., Wierling, C., Lehrach, H., & Herwig, R. (2008). ConsensusPathDB—a database for integrating human functional interaction networks. Nucleic Acids Research, 37(Database issue), D623-D628. doi:10.1093/nar/gkn698.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7ED5-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7ED6-B
Genre: Journal Article
Alternative Title : Nucleic Acids Res

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 Creators:
Kamburov, Atanas1, Author              
Wierling, Christoph2, Author              
Lehrach, Hans3, Author              
Herwig, Ralf1, Author              
Affiliations:
1Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              
2Systems Biology (Christoph Wierling), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479656              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: ConsensusPathDB is a database system for the integration of human functional interactions. Current knowledge of these interactions is dispersed in more than 200 databases, each having a specific focus and data format. ConsensusPathDB currently integrates the content of 12 different interaction databases with heterogeneous foci comprising a total of 26 133 distinct physical entities and 74 289 distinct functional interactions (protein–protein interactions, biochemical reactions, gene regulatory interactions), and covering 1738 pathways. We describe the database schema and the methods used for data integration. Furthermore, we describe the functionality of the ConsensusPathDB web interface, where users can search and visualize interaction networks, upload, modify and expand networks in BioPAX, SBML or PSI-MI format, or carry out over-representation analysis with uploaded identifier lists with respect to substructures derived from the integrated interaction network. The ConsensusPathDB database is available at: http://cpdb.molgen.mpg.de

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Language(s): eng - English
 Dates: 2008-10-21
 Publication Status: Published in print
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Title: Nucleic Acids Research
  Alternative Title : Nucleic Acids Res
Source Genre: Journal
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Pages: - Volume / Issue: 37 (Database issue) Sequence Number: - Start / End Page: D623 - D628 Identifier: ISSN: 1362-4962