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  Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

Hufton, A. L., Groth, D., Vingron, M., Lehrach, H., Poustka, A. J., & Panopoulou, G. (2008). Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement. Genome Research, 18(10), 1582-1591. doi:10.1101/gr.080119.108.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7EF3-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7EF4-5
Genre: Journal Article
Alternative Title : Genome Res

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 Creators:
Hufton, Andrew L.1, Author
Groth, Detlef1, Author
Vingron, Martin2, Author              
Lehrach, Hans3, Author              
Poustka, Albert J.4, Author              
Panopoulou, Georgia4, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
4Evolution and Development (Albert Poustka), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479650              

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 Abstract: Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important implications for vertebrate evolution. Benefiting from the newly released amphioxus genome sequence (Branchiostoma floridae), an invertebrate that researchers have hoped is representative of the ancestral chordate genome, we have used gene proximity conservation to estimate rates of genome rearrangement throughout vertebrates and some of their invertebrate ancestors. We find that, while amphioxus remains the best single source of invertebrate information about the early chordate genome, its genome structure is not particularly well conserved and it cannot be considered a fossilization of the vertebrate preduplication genome. In agreement with previous reports, we identify two WGD events in early vertebrates and another in teleost fish. However, we find that the early vertebrate WGD events were not followed by increased rates of genome rearrangement. Indeed, we measure massive genome rearrangement prior to these WGD events. We propose that the vertebrate WGD events may have been symptoms of a preexisting predisposition toward genomic structural change.

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Language(s): eng - English
 Dates: 2008-10
 Publication Status: Published in print
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Title: Genome Research
  Alternative Title : Genome Res
Source Genre: Journal
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Pages: - Volume / Issue: 18 (10) Sequence Number: - Start / End Page: 1582 - 1591 Identifier: ISSN: 1088-9051