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  An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors

Muradyan, A., Boldt, V., Steininger, A., Stabentheiner, S., Tebel, K., Kreutzberger, J., et al. (2008). An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors. Archives of Pathology and Laboratory Medicine, 132(10), 1557-1561. Retrieved from http://arpa.allenpress.com/pdfserv/10.1043%2F1543-2165(2008)132%5B1557:AIAFAT%5D2.0.CO%3B2.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7EF7-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7EF8-E
Genre: Journal Article

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 Creators:
Muradyan, Artur1, Author              
Boldt, Vivien2, Author              
Steininger, Anne2, Author              
Stabentheiner, Stephanie3, Author
Tebel, Katrin2, Author              
Kreutzberger, Jürgen1, Author              
Müller, Ines2, Author              
Madle, Hannelore3, Author
Popper, Helmut H., Author
Ullmann, Reinhard2, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Molecular Cytogenetics (Reinhard Ullmann), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479645              
3Max Planck Society, ou_persistent13              

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 Abstract: The accumulation of chromosomal aberrations is a characteristic feature of tumor development. However, an understanding of tumorigenesis that assumes that changes in DNA copy number always cause equivalent changes in the corresponding RNA and protein levels is an oversimplification and completely ignores the individual genetic and epigenetic context in which an aberration has to be evaluated. We present a brief introduction to various techniques dedicated to the genome-wide analysis of genetic and epigenetic changes, and illustrate how complementary information derived from these various DNA array-based technologies can lead to a better understanding of the consequences of chromosomal aberrations.

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Language(s): eng - English
 Dates: 2008-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Archives of Pathology and Laboratory Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 132 (10) Sequence Number: - Start / End Page: 1557 - 1561 Identifier: -