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  Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton

Goswami, C., & Hucho, T. (2008). Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton. FEBS Journal, 275(19), 4684-4699. doi:10.1111/j.1742-4658.2008.06617.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7F34-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7F35-B
Genre: Journal Article

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 Creators:
Goswami, Chandan1, Author              
Hucho, Tim2, Author              
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Signal Transduction in Mental Retardation and Pain (Tim Hucho), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479646              

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Free keywords: actin • axonal guidence • cytoskeleton • growth cone • myosin • pain • signalling complex • transient receptor potential channels • tubulin • varicosity
 Abstract: Much work has focused on the electrophysiological properties of transient receptor potential channels. Recently, a novel aspect of importance emerged: the interplay of transient receptor potential channels with the cytoskeleton. Recent data suggest a direct interaction and functional repercussion for both binding partners. The bi-directionality of physical and functional interaction renders therefore, the cytoskeleton a potent integration point of complex biological signalling events, from both the cytoplasm and the extracellular space. In this minireview, we focus mostly on the interaction of the cytoskeleton with transient receptor potential vanilloid channels. Thereby, we point out the functional importance of cytoskeleton components both as modulator and as modulated downstream effector. The resulting implications for patho-biological situations are discussed.

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Language(s): eng - English
 Dates: 2008-08-27
 Publication Status: Published in print
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Title: FEBS Journal
Source Genre: Journal
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Pages: - Volume / Issue: 275 (19) Sequence Number: - Start / End Page: 4684 - 4699 Identifier: -