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  Autoregulation of Th1-mediated inflammation by twist1

Niesner, U., Albrecht, I., Janke, M., Doebis, C., Loddenkemper, C., Lexberg, M. H., et al. (2008). Autoregulation of Th1-mediated inflammation by twist1. Journal of Experimental Medicine, 205(8), 1889-1901. doi:10.1084/jem.20072468.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7F5D-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7F5E-4
Genre: Journal Article
Alternative Title : J Exp Med

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 Creators:
Niesner, Uwe, Author
Albrecht, Inka, Author
Janke, Marko, Author
Doebis, Cornelia, Author
Loddenkemper, Christoph, Author
Lexberg, Maria H., Author
Eulenburg, Katharina, Author
Kreher, Stephan, Author
Koeck, Juliana, Author
Baumgrass, Ria, Author
Bonhagen, Kerstin, Author
Kamradt, Thomas, Author
Enghard, Philipp, Author
Humrich, Jens Y., Author
Rutz, Sascha, Author
Schulze-Topphoff, Ulf, Author
Aktas, Orhan, Author
Bartfeld, Sina, Author
Radbruch, Helena, Author
Hegazy, Ahmed N., Author
Löhning, Max, AuthorBaumgart, Daniel C., AuthorDuchmann, Rainer, AuthorRudwaleit, Martin, AuthorHäupl, Thomas, AuthorGitelman, Inna, AuthorKrenn, Veit, AuthorGruen, Joachim, AuthorSieper, Jochen, AuthorZeitz, Martin, AuthorWiedenmann, Bertram, AuthorZipp, Frauke, AuthorHamann, Alf, AuthorJanitz, Michal1, Author              Scheffold, Alexander, AuthorBurmester, Gerd R., AuthorChang, Hyun D., AuthorRadbruch, Andreas, Author more..
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor {kappa}B (NF-{kappa}B)–dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We show that twist1 is expressed by activated T helper (Th) 1 effector memory (EM) cells. Induction of twist1 in Th cells depended on NF-{kappa}B, nuclear factor of activated T cells (NFAT), and interleukin (IL)-12 signaling via signal transducer and activator of transcription (STAT) 4. Expression of twist1 was transient after T cell receptor engagement, and increased upon repeated stimulation of Th1 cells. Imprinting for enhanced twist1 expression was characteristic of repeatedly restimulated EM Th cells, and thus of the pathogenic memory Th cells characteristic of chronic inflammation. Th lymphocytes from the inflamed joint or gut tissue of patients with rheumatic diseases, Crohn's disease or ulcerative colitis expressed high levels of twist1. Expression of twist1 in Th1 lymphocytes limited the expression of the cytokines interferon-{gamma}, IL-2, and tumor necrosis factor-{alpha}, and ameliorated Th1-mediated immunopathology in delayed-type hypersensitivity and antigen-induced arthritis.

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Language(s): eng - English
 Dates: 2008-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Journal of Experimental Medicine
  Alternative Title : J Exp Med
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 205 (8) Sequence Number: - Start / End Page: 1889 - 1901 Identifier: ISSN: 0022-1007