English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Protein Phosphatase 2A and Rapamycin regulate the nuclear localization and activity of the transcription factor GLI3

Krauß, S., Foerster, J., Schneider, R., & Schweiger, S. (2008). Protein Phosphatase 2A and Rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Research, 68(12), 4658-4665. Retrieved from http://cancerres.aacrjournals.org/cgi/reprint/68/12/4658.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7FAF-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-429B-3
Genre: Journal Article
Alternative Title : Cancer Res

Files

show Files
hide Files
:
4658.pdf (Any fulltext), 439KB
 
File Permalink:
-
Name:
4658.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Molecular Genetics, MBMG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: INSTITUT
License:
-

Locators

show

Creators

show
hide
 Creators:
Krauß, Sybille1, Author
Foerster, John, Author
Schneider, Rainer2, Author              
Schweiger, Susann2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

Content

show
hide
Free keywords: -
 Abstract: Gain-of-function alterations to the sonic hedgehog (SHH) signaling cascade have been found in a wide range of tumors. Three SHH effectors, GLI1, GLI2, and GLI3, regulate transcription of diverse genes involved in cell growth and cell proliferation. Here, we show that protein phosphatase 2A (PP2A), its regulatory subunit, alpha4, and rapamycin, an inhibitor of the mammalian target of rapamycin kinase complex 1 (mTORC1), regulate the nuclear localization and transcriptional activity of GLI3. An increase in PP2A activity or treatment with rapamycin leads to cytosolic retention of GLI3 and, consequently, reduced transcription of the GLI3 target gene and cell cycle regulator, cyclin D1. Conversely, inhibition of PP2A results in increased expression of cyclin D1. In summary, our findings reveal the existence of a hitherto unrecognized molecular cross-talk between the oncogenic SHH pathway and the tumor suppressor PP2A and suggest a novel mechanism underlying the anticancerogenic effects of rapamycin.

Details

show
hide
Language(s): eng - English
 Dates: 2008-06-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cancer Research
  Alternative Title : Cancer Res
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 68 (12) Sequence Number: - Start / End Page: 4658 - 4665 Identifier: -