Arp3 is required during preimplantation development of the mouse embryo

Vauti, Franz; Prochnow, Blair Raymond; Freese, Elke; Ramasamy, Suresh Kumar; Ruiz, Patricia; Arnold, Hans-Henning

doi:10.1016/j.febslet.2007.11.031

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Arp3 is required during preimplantation development of the mouse embryo

Vauti, F., Prochnow, B. R., Freese, E., Ramasamy, S. K., Ruiz, P., & Arnold, H.-H. (2007). Arp3 is required during preimplantation development of the mouse embryo. FEBS Letters, 581(29), 5691-5697. doi:10.1016/j.febslet.2007.11.031.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8101-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8102-0

Genre: Journal Article

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Creators:
Vauti, Franz, Author
Prochnow, Blair Raymond, Author
Freese, Elke, Author
Ramasamy, Suresh Kumar, Author
Ruiz, Patricia¹, Author
Arnold, Hans-Henning, Author

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1Max Planck Society, ou_persistent13

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Free keywords: Arp3-deficient mouse; Embryonic lethality; Abnormal blastocysts

Abstract: The role of Arp3 in mouse development was investigated utilizing a gene trap mutation in the Arp3 gene. Heterozygous Arp3WT/GT mice are normal, however, homozygous Arp3GT/GT embryos die at blastocyst stage. Earlier embryonic stages appear unaffected by the mutation, probably due to maternal Arp3 protein. Mutant blastocysts isolated at E3.5 fail to continue development in vitro, lack outgrowth of trophoblast-like cells in culture and express reduced levels of the trophoblast marker Cdx2, while markers for inner cell mass continue to be present. The recessive embryonic lethal phenotype indicates that Arp3 plays a vital role for early mouse development, possibly when trophoblast cells become critical for implantation.

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Language(s): eng - English

Dates: Date issued: 2007-12-11

Publication Status: Issued

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Identifiers: eDoc: 335961
DOI: 10.1016/j.febslet.2007.11.031
URI: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T36-4R5X0JR-2-F&_cdi=4938&_user=28761&_orig=browse&_coverDate=12%2F11%2F2007&_sk=994189970&view=c&wchp=dGLbVzb-zSkzV&md5=e4be8549e8b04c6c3aa35c5bfa66c35c&ie=/sdarticle.pdf

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Title: FEBS Letters

Source Genre: Journal

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Pages: - Volume / Issue: 581 (29) Sequence Number: - Start / End Page: 5691 - 5697 Identifier: ISSN: 0014-5793