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  TLR2 has a detrimental role in mouse transient focal cerebral ischemia

Ziegler, G., Harhausen, D., Schepers, C., Hoffmann, O., Röhr, C., Prinz, V., et al. (2007). TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochemical and Biophysical Research Communications (Orlando, FL), 359(3), 574-579. doi:10.1016/j.bbrc.2007.05.157.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-818A-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-818B-B
Genre: Journal Article
Alternative Title : Biochem Biophys Res Commun

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 Creators:
Ziegler, Gina1, Author              
Harhausen, Denise, Author
Schepers, Claudia2, Author
Hoffmann, Olaf, Author
Röhr, Christina3, Author              
Prinz, Vincent, Author
König, Janett, Author
Lehrach, Hans1, Author              
Nietfeld, Wilfried1, Author              
Trendelenburg, George, Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Max Planck Society, ou_persistent13              
3Cancer Genomics (Michal-Ruth Schweiger), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479649              

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Free keywords: Cerebral ischemia; Toll-like receptor; TLR2; Stroke; MCAO; Knockout mice
 Abstract: A significant up-regulation of Toll-like-receptor (TLR) mRNAs between 3 and 48 h reperfusion time after induction of transient focal cerebral ischemia for 1 h was revealed by applying global gene expression profiling in postischemic mouse brains. Compared to TLR4 and TLR9, TLR2 proved to be the most significantly up-regulated TLR in the ipsilateral brain hemisphere. TLR2-protein was found to be expressed mainly in microglia in the postischemic brain tissue, but also in selected endothelial cells, neurons, and astrocytes. Additionally, TLR2-related genes with pro-inflammatory and pro-apoptotic capabilities were induced. Therefore we hypothesized that TLR2-signaling could exacerbate the primary brain damage after ischemia. Two days after induction of transient focal cerebral ischemia (1 h), we found a significant decrease of the infarct volume in TLR2 deficient mice compared to wild type mice (75 ± 5 vs. 42 ± 7 mm3). We conclude that TLR2 up-regulation and TLR2-signaling are important events in focal cerebral ischemia and contribute to the deterioration of ischemic damage.

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Language(s): eng - English
 Dates: 2007-08-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Biochemical and Biophysical Research Communications (Orlando, FL)
  Alternative Title : Biochem Biophys Res Commun
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 359 (3) Sequence Number: - Start / End Page: 574 - 579 Identifier: ISSN: 0006-291X