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  Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.

Wittler, L., Shin, E.-h., Grote, P., Kispert, A., Beckers, A., Gossler, A., et al. (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Reports, 8(8), 784-789. doi:10.1038/sj.embor.7401030.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-819B-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-819D-3
Genre: Journal Article
Alternative Title : EMBO reports

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7401030.pdf (Any fulltext), 237KB
 
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 Creators:
Wittler, Lars1, Author              
Shin, Eun-ha2, Author              
Grote, Phillip2, Author              
Kispert, Andreas, Author
Beckers, Anja, Author
Gossler, Achim, Author
Werber, Martin2, Author              
Herrmann, Bernhard G.2, Author              
Affiliations:
1Transgene Unit (Head: Lars Wittler), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479663              
2Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: The vertebral column and skeletal muscles of vertebrates are derived from the paraxial mesoderm, which is laid down initially as two stripes of mesenchymal cells alongside the neural tube and subsequently segmented. Previous work has shown that the wingless-type MMTV integration site family (WNT), fibroblast growth factor- and Delta–Notch signalling pathways control presomitic mesoderm (psm) formation and segmentation. Here, we show that the expression of mesogenin 1, a basic helix–loop–helix transcription factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism. These findings emphasize the crucial role of WNT signalling in the control of psm formation, maturation and segmentation.

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Language(s): eng - English
 Dates: 2007-08-01
 Publication Status: Published in print
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 Identifiers: eDoc: 337586
DOI: 10.1038/sj.embor.7401030
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Title: EMBO Reports
  Alternative Title : EMBO reports
Source Genre: Journal
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Pages: - Volume / Issue: 8 (8) Sequence Number: - Start / End Page: 784 - 789 Identifier: ISSN: 1469-221X