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  c-Met is essential for wound healing in the skin.

Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T., Munz, B., Werner, S., et al. (2007). c-Met is essential for wound healing in the skin. The Journal of Cell Biology: JCB, 177(1), 151-162. doi:10.1083/jcb.200701086.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-828F-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8290-6
Genre: Journal Article
Alternative Title : J. Cell Biol.

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 Creators:
Chmielowiec, Jolanta, Author
Borowiak, Malgorzata, Author
Morkel, Markus1, Author              
Stradal, Theresia, Author
Munz, Barbara, Author
Werner, Sabine, Author
Wehland, Jürgen, Author
Birchmeier, Carmen, Author
Birchmeier, Walter, Author
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1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: Wound healing of the skin is a crucial regenerative process in adult mammals. We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre recombinase. c-Met–deficient keratinocytes were unable to contribute to the reepithelialization of skin wounds. In conditional c-Met mutant mice, wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination. This demonstrates that the wound process selected and amplified residual cells that express a functional c-Met receptor. We also cultured primary keratinocytes from the skin of conditional c-Met mutant mice and examined them in scratch wound assays. Again, closure of scratch wounds occurred by the few remaining c-Met–positive cells. Our data show that c-Met signaling not only controls cell growth and migration during embryogenesis but is also essential for the generation of the hyperproliferative epithelium in skin wounds, and thus for a fundamental regenerative process in the adult.

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Language(s): eng - English
 Dates: 2007-01-01
 Publication Status: Published in print
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Title: The Journal of Cell Biology : JCB
  Alternative Title : J. Cell Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 177 (1) Sequence Number: - Start / End Page: 151 - 162 Identifier: ISSN: 0021-9525