English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse.

Bauer, H., Véron, N., Willert, J., & Herrmann, B. G. (2007). The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes & Development: A Journal of Celluar and Molecular Biology, 21(1), 143-147. doi:10.1101/gad.414807.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Genes Dev

Files

show Files
hide Files
:
143.pdf (Any fulltext), 583KB
 
File Permalink:
-
Name:
143.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Molecular Genetics, MBMG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: INSTITUT
License:
-

Locators

show

Creators

show
hide
 Creators:
Bauer, Hermann1, Author              
Véron, Nathalie2, Author
Willert, Jürgen1, Author              
Herrmann, Bernhard G.1, Author              
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              
2Max Planck Society, ou_persistent13              

Content

show
hide
Free keywords: Mouse; transmission ratio distortion; testis; sperm motility; Rho; G proteins
 Abstract: Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1–4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype th49, directly demonstrating the role of Fgd2 as Distorter. Fgd2 identifies a second Rho G protein signaling pathway promoting TRD.

Details

show
hide
Language(s): eng - English
 Dates: 2007-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genes & Development : A Journal of Celluar and Molecular Biology
  Alternative Title : Genes Dev
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 21 (1) Sequence Number: - Start / End Page: 143 - 147 Identifier: ISSN: 0890-9369