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  Analysis of fused in-situ hybridization and gene expression data.

Opitz, L., Schliep, A., & Posch, A. (2007). Analysis of fused in-situ hybridization and gene expression data. In Advances in Data Analysis (pp. 577-584). Berlin/Heidelberg: Springer.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-82DE-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-82DF-9
Genre: Book Chapter

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 Creators:
Opitz, L., Author
Schliep, Alexander1, Author           
Posch, A., Author
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              

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Free keywords: * Classification Clustering Data Analysis Data Mining Information Retrieval Machine Learning
 Abstract: To understand transcriptional regulation during development a detailed analysis of gene expression is needed. In-situ hybridization experiments measure the spatial distribution of mRNA-molecules and thus complement DNA-microarray experiments. This is of very high biological relevance, as co-location is a necessary condition for possible molecular interactions. We use publicly available in-situ data from embryonal development of Drosophila and derive a co-location index for pairs of genes. Our image processing pipeline for in-situ images provides a simpler alternative for the image processing part at comparable performance compared to published prior work. We formulate a mixture model which can use the pair-wise co-location indices as constraints in a mixture estimation on gene expression time-courses.

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Language(s): eng - English
 Dates: 2007
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 336979
 Degree: -

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Title: Advances in Data Analysis
Source Genre: Book
 Creator(s):
Decker, Reinhold, Author
Lenz, Hans-Joachim, Author
Affiliations:
-
Publ. Info: Berlin/Heidelberg : Springer
Pages: XVI, 687 p. 202 illus.. Volume / Issue: - Sequence Number: - Start / End Page: 577 - 584 Identifier: ISBN: 978-3-540-70980-0

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Title: Studies in Classification, Data Analysis, and Knowledge Organization
Source Genre: Series
 Creator(s):
Decker, Reinhold, Editor
Lenz, Hans-Joachim, Editor
Affiliations:
-
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: -