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  A centrosome-independent role for {gamma}-TuRC proteins in the spindle assembly checkpoint

Müller, H., Fogeron, M.-L., Lehmann, V., Lehrach, H., & Lange, B. M. H. (2006). A centrosome-independent role for {gamma}-TuRC proteins in the spindle assembly checkpoint. Science, 314(5799), 654-657. doi:10.1126/science.1132834.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8367-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8368-9
Genre: Journal Article

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 Creators:
Müller, Hannah1, Author              
Fogeron, Marie-Laure1, Author              
Lehmann, Verena2, Author
Lehrach, Hnas2, Author
Lange, Bodo M. H.1, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Max Planck Society, ou_persistent13              

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 Abstract: The spindle assembly checkpoint guards the fidelity of chromosome segregation. It requires the close cooperation of cell cycle regulatory proteins and cytoskeletal elements to sense spindle integrity. The role of the centrosome, the organizing center of the microtubule cytoskeleton, in the spindle checkpoint is unclear. We found that the molecular requirements for a functional spindle checkpoint included components of the large {gamma}-tubulin ring complex ({gamma}-TuRC). However, their localization at the centrosome and centrosome integrity were not essential for this function. Thus, the spindle checkpoint can be activated at the level of microtubule nucleation.

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Language(s): eng - English
 Dates: 2006-10-27
 Publication Status: Published in print
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 Identifiers: eDoc: 309980
DOI: 10.1126/science.1132834
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 314 (5799) Sequence Number: - Start / End Page: 654 - 657 Identifier: ISSN: 0036-8075