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  Arteries define the position of the thyroid gland during its developmental relocalisation

Alt, B., Elsalini, O. A., Schrumpf, P., Haufs, N., Lawson, N. D., Schwabe, G. C., et al. (2006). Arteries define the position of the thyroid gland during its developmental relocalisation. Development, 133(19), 3797-3804. doi:10.1242/10.1242/dev.02550.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-838D-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-838E-6
Genre: Journal Article

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 Creators:
Alt, Burkhard, Author
Elsalini, Osama A., Author
Schrumpf, Pamela, Author
Haufs, Nele, Author
Lawson, Nathan D., Author
Schwabe, Georg C.1, Author              
Mundlos, Stefan1, Author              
Grüters, Annette, Author
Krude, Heiko, Author
Rohr, Klaus B., Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Thyroid; Zebrafish; Mouse; Arteries; Vegf; Scl; Hedgehog
 Abstract: During vertebrate development, the thyroid gland undergoes a unique relocalisation from its site of induction to a distant species-specific position in the cervical mesenchyme. We have analysed thyroid morphogenesis in wild-type and mutant zebrafish and mice, and find that localisation of growing thyroid tissue along the anteroposterior axis in zebrafish is linked to the development of the ventral aorta. In grafting experiments, ectopic vascular cells influence the localisation of thyroid tissue cell non-autonomously, showing that vessels provide guidance cues in zebrafish thyroid morphogenesis. In mouse thyroid development, the midline primordium bifurcates and two lobes relocalise cranially along the bilateral pair of carotid arteries. In hedgehog-deficient mice, thyroid tissue always develops along the ectopically and asymmetrically positioned carotid arteries, suggesting that, in mice (as in zebrafish), co-developing major arteries define the position of the thyroid. The similarity between zebrafish and mouse mutant phenotypes further indicates that thyroid relocalisation involves two morphogenetic phases, and that variation in the second phase accounts for species-specific differences in thyroid morphology. Moreover, the involvement of vessels in thyroid relocalisation sheds new light on the interpretation of congenital thyroid defects in humans.

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Language(s): eng - English
 Dates: 2006-10-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 313078
DOI: 10.1242/10.1242/dev.02550
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Title: Development
Source Genre: Journal
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Pages: - Volume / Issue: 133 (19) Sequence Number: - Start / End Page: 3797 - 3804 Identifier: ISSN: 0950-1991