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  A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling

Hummel, M., Bentink, S., Berger, H., Klapper, W., Wessendorf, S., Barth, T. F., et al. (2006). A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling. The New England Journal of Medicine: NEJM / Publ. by the Massachusetts Medical Society, 354(23), 2419-2430.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8419-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-841A-6
Genre: Journal Article
Alternative Title : N. Engl. J. Med.

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 Creators:
Hummel, Michael, Author
Bentink, Stefan1, Author
Berger, Hilmar, Author
Klapper, Wolfram, Author
Wessendorf, Swen, Author
Barth, Thomas F.E., Author
Bernd, Heinz-Wolfram, Author
Cogliatti, Sergio B., Author
Dierlamm, Judith, Author
Feller, Alfred C., Author
Hansmann, Martin-Leo, Author
Haralambieva, Eugenia, Author
Harder, Lana, Author
Hasenclever, Dirk, Author
Kühn, Michael, Author
Lenze, Dido, Author
Lichter, Peter, Author
Martin-Subero, Jose Ignacio, Author
Möller, Peter, Author
Müller-Hermelink, Hans-Konrad, Author
Ott, German, AuthorParwaresch, Reza M., AuthorPott, Christiane, AuthorRosenwald, Andreas, AuthorRosolowski, Maciej, AuthorSchwaenen, Carsten, AuthorStürzenhofecker, Benjamin, AuthorSzczepanowski, Monika, AuthorTrautmann, Heiko, AuthorWacker, Hans-Heinrich, AuthorSpang, Rainer2, Author              Loeffler, Markus, AuthorTrümper, Lorenz, AuthorStein, Harald, AuthorSiebert, Reiner, Author more..
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              

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 Abstract: Background: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is unclear. We used transcriptional and genomic profiling to define Burkitt's lymphoma more precisely and to distinguish subgroups in other types of mature aggressive B-cell lymphomas. Methods: We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization. Results: We used the molecular signature for Burkitt's lymphoma to identify 44 cases: 11 had the morphologic features of diffuse large-B-cell lymphomas, 4 were unclassifiable mature aggressive B-cell lymphomas, and 29 had a classic or atypical Burkitt's morphologic appearance. Also, five did not have a detectable IG-myc Burkitt's translocation, whereas the others contained an IG-myc fusion, mostly in simple karyotypes. Of the 176 lymphomas without the molecular signature for Burkitt's lymphoma, 155 were diffuse large-B-cell lymphomas. Of these 155 cases, 21 percent had a chromosomal breakpoint at the myc locus associated with complex chromosomal changes and an unfavorable clinical course. Conclusions: Our molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt's lymphoma. In mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome.

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Language(s): eng - English
 Dates: 2006-06-08
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: eDoc: 309275
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Title: The New England Journal of Medicine : NEJM / Publ. by the Massachusetts Medical Society
  Alternative Title : N. Engl. J. Med.
Source Genre: Journal
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Pages: - Volume / Issue: 354 (23) Sequence Number: - Start / End Page: 2419 - 2430 Identifier: ISSN: 0028-4793