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  Platelet-derived serotonin mediates liver regeneration

Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., et al. (2006). Platelet-derived serotonin mediates liver regeneration. Science, 312(5770), 104-107. doi:10.1126/science.1123842.

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Genre: Journal Article
Alternative Title : Scie

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 Creators:
Lesurtel, Mickael, Author
Graf, Rolf, Author
Aleil, Boris, Author
Walther, Diego J.1, Author              
Tian, Yinghua, Author
Jochum, Wolfram, Author
Gachet, Christian, Author
Bader, Michael, Author
Clavien, Pierre-Alain, Author
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1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.

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Language(s): eng - English
 Dates: 2006-04-07
 Publication Status: Published in print
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 Identifiers: eDoc: 307708
DOI: 10.1126/science.1123842
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Title: Science
  Alternative Title : Scie
Source Genre: Journal
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Pages: - Volume / Issue: 312 (5770) Sequence Number: - Start / End Page: 104 - 107 Identifier: ISSN: 0036-8075