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  Hormonal Control of C. elegans Dauer Formation and Life Span by a Rieske-like Oxygenase

Rottiers, V., Motola, D. L., Gerisch, B., Cummins, C. L., Nishiwaki, K., Mangelsdorf, D. J., et al. (2006). Hormonal Control of C. elegans Dauer Formation and Life Span by a Rieske-like Oxygenase. Developmental Cell, 10(4), 473-482. doi:10.1016/j.devcel.2006.02.008.

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Genre: Journal Article
Alternative Title : Dev Cell

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 Creators:
Rottiers, Veerle, Author
Motola, Daniel L., Author
Gerisch, Birgit1, Author              
Cummins, Carolyn L., Author
Nishiwaki, Kiyoji, Author
Mangelsdorf, David J.2, Author
Antebi, Adam3, Author              
Affiliations:
1Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              
2Max Planck Society, ou_persistent13              
3Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

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Free keywords: SIGNALING; DEVBIO
 Abstract: C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which serves as a ligand to the nuclear hormone receptor DAF-12. A key step in hormone production is catalyzed by the CYP450 DAF-9, but the extent of the biosynthetic pathway is unknown. Here, we identify a conserved Rieske-like oxygenase, DAF-36, as a component in hormone metabolism. Mutants display larval developmental and adult aging phenotypes, as well as patterns of epistasis similar to that of daf-9. Larval phenotypes are potently reversed by crude lipid extracts, 7-dehydrocholesterol, and a recently identified DAF-12 sterol ligand, suggesting that DAF-36 works early in the hormone biosynthetic pathway. DAF-36 is expressed primarily within the intestine, a major organ of metabolic and endocrine control, distinct from DAF-9. These results imply that C. elegans hormone production has multiple steps and is distributed, and that it may provide one way that tissues register their current physiological state during organismal commitments.

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Language(s): eng - English
 Dates: 2006-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 313077
DOI: 10.1016/j.devcel.2006.02.008
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Title: Developmental Cell
  Alternative Title : Dev Cell
Source Genre: Journal
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Pages: - Volume / Issue: 10 (4) Sequence Number: - Start / End Page: 473 - 482 Identifier: ISSN: 1534-5807