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  A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris

Yan, K.-L., Zhang, X.-J., Wang, Z.-M., Yang, S., Zhang, G.-L., Wang, J., et al. (2006). A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. The Journal of Investigative Dermatology: Official Journal of the Society for Investigative Dermatology and the European Society for Dermatological Research, 126(5), 1003-1005. doi:10.1038/sj.jid.5700186.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8488-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8489-E
Genre: Journal Article
Alternative Title : J. Invest. Dermatol.

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 Creators:
Yan, Kai-Lin, Author
Zhang, Xue-Jun, Author
Wang, Zhi-Min, Author
Yang, Sen, Author
Zhang, Guo-Long, Author
Wang, Jian, Author
Xiao, Feng-Li, Author
Gao, Min, Author
Cui, Yong, Author
Chen, Jian-Jun, Author
Fan, Xing, Author
Sun, Liang-Dan, Author
Xia, Qing, Author
Zhang, Kai-Yue, Author
Niu, Zhen-Min, Author
Xu, Shi-Jie, Author
Tzschach, Andreas1, Author              
Ropers, Hans-Hilger1, Author              
Huang, Wei, Author
Liu, Jian-Jun, Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Free keywords: MGST2, microsomal glutathione S-transferase 2
 Abstract: A balanced translocation was recently identified in a German psoriasis patient. One of the breakpoints was mapped immediately upstream of the microsomal glutathione S-transferase 2 (MGST2) gene, suggesting it as a candidate gene. Here, we report the identification of a novel non-synonymous mutation in MGST2 by a comprehensive sequence analysis of MGST2's coding region in Chinese psoriasis samples. We demonstrate that this mutation co-segregated with the disease phenotype within a Chinese family affected with psoriasis vulgaris and is predicted to have an impact on the normal function of MGST2 protein. However, the mutation was absent in 551 additional cases and 384 healthy Chinese controls. While requiring independent confirmation, our results suggest that this rare mutation could play a causal role in a small subset of psoriasis individuals.

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Language(s): eng - English
 Dates: 2006-02-23
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 309220
DOI: 10.1038/sj.jid.5700186
 Degree: -

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Title: The Journal of Investigative Dermatology : Official Journal of the Society for Investigative Dermatology and the European Society for Dermatological Research
  Alternative Title : J. Invest. Dermatol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 126 (5) Sequence Number: - Start / End Page: 1003 - 1005 Identifier: ISSN: 0022-202x