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  Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1

Kube, M., Beck, A., Zinder, S. H., Kuhl, H., Reinhardt, R., & Adrian, L. (2005). Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1. Nature Biotechnology, 23, 1269-1273. doi:10.1038/nbt1131.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-85BE-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-85BF-E
Genre: Journal Article
Alternative Title : Nat Biotechnol

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 Creators:
Kube, Michael1, Author              
Beck, Alfred2, Author              
Zinder, Stephen H., Author
Kuhl, Heiner3, Author              
Reinhardt, Richard1, Author              
Adrian, Lorenz, Author
Affiliations:
1High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              
2Computing (Head: Donald Buczek/Peter Marquardt), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479667              
3Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Dehalococcoides species are strictly anaerobic bacteria, which catabolize many of the most toxic and persistent chlorinated aromatics and aliphatics by reductive dechlorination and are used for in situ bioremediation of contaminated sites. Our sequencing of the complete 1,395,502 base pair genome of Dehalococcoides strain CBDB1 has revealed the presence of 32 reductive-dehalogenase-homologous (rdh) genes, possibly conferring on the bacteria an immense dehalogenating potential. Most rdh genes were associated with genes encoding transcription regulators such as two-component regulatory systems or transcription regulators of the MarR-type. Four new paralog groups of rdh-associated genes without known function were detected. Comparison with the recently sequenced genome of Dehalococcoides ethenogenes strain 195 reveals a high degree of gene context conservation (synteny) but exceptionally high plasticity in all regions containing rdh genes, suggesting that these regions are under intense evolutionary pressure.

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Language(s): eng - English
 Dates: 2005-08-21
 Publication Status: Published in print
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 Identifiers: eDoc: 273063
DOI: 10.1038/nbt1131
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Title: Nature Biotechnology
  Alternative Title : Nat Biotechnol
Source Genre: Journal
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Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 1269 - 1273 Identifier: ISSN: 1087-0156