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  The genome of the kinetoplastid parasite, Leishmania major

Beck, A., Borzym, K., Klages, S., Kube, M., Reinhardt, R., & et al,. (2005). The genome of the kinetoplastid parasite, Leishmania major. Science, 309(5733), 436-442. doi:10.1126/science.1112680.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-85F2-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-85F3-3
Genre: Journal Article
Alternative Title : Scie

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 Creators:
Beck, Alfred1, Author              
Borzym, Katja2, Author              
Klages, Sven3, Author              
Kube, Michael4, Author              
Reinhardt, Richard4, Author              
et al, ..., Author
Affiliations:
1Computing (Head: Donald Buczek/Peter Marquardt), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479667              
2Mechanisms of Transcriptional Regulation (Sebastiaan H. Meijsing), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479641              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
4High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

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 Abstract: Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.

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Language(s): eng - English
 Dates: 2005-07-15
 Publication Status: Published in print
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 Identifiers: eDoc: 273050
DOI: 10.1126/science.1112680
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Title: Science
  Alternative Title : Scie
Source Genre: Journal
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Pages: - Volume / Issue: 309 (5733) Sequence Number: - Start / End Page: 436 - 442 Identifier: ISSN: 0036-8075