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  Male-Driven Biased Gene Conversion Governs the Evolution of Base Composition in Human Alu Repeats

Webster, M. T., Smith, N. G. C., Hultin-Rosenberg, L., Arndt, P. F., & Ellegren, H. (2005). Male-Driven Biased Gene Conversion Governs the Evolution of Base Composition in Human Alu Repeats. Molecular Biology and Evolution, 22(6), 1468-1474. doi:10.1093/molbev/msi136.

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Genre: Journal Article
Alternative Title : Mol Biol Evol.

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 Creators:
Webster, Matthew T., Author
Smith, Nick G. C., Author
Hultin-Rosenberg, Lina, Author
Arndt, Peter F.1, Author           
Ellegren, Hans, Author
Affiliations:
1Evolutionary Genomics (Peter Arndt), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479638              

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Free keywords: isochore base composition Alu mutation recombination SNP
 Abstract: Regional biases in substitution pattern are likely to be responsible for the large-scale variation in base composition observed in vertebrate genomes. However, the evolutionary forces responsible for these biases are still not clearly defined. In order to study the processes of mutation and fixation across the entire human genome, we analyzed patterns of substitution in Alu repeats since their insertion. We also studied patterns of human polymorphism within the repeats. There is a highly significant effect of recombination rate on the pattern of substitution, whereas no such effect is seen on the pattern of polymorphism. These results suggest that regional biases in substitution are caused by biased gene conversion, a process that increases the probability of fixation of mutations that increase GC content. Furthermore, the strongest correlate of substitution patterns is found to be male recombination rates rather than female or sex-averaged recombination rates. This indicates that in addition to sexual dimorphism in recombination rates, the sexes also differ in the relative rates of crossover and gene conversion.

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Language(s): eng - English
 Dates: 2005-03-16
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 268533
DOI: 10.1093/molbev/msi136
 Degree: -

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Title: Molecular Biology and Evolution
  Alternative Title : Mol Biol Evol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 22 (6) Sequence Number: - Start / End Page: 1468 - 1474 Identifier: ISSN: 0737-4038