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  Epigenetics, chromatin, and stem cells

Roloff, T. C., & Nuber, U. A. (2005). Epigenetics, chromatin, and stem cells. European Journal of Cell Biology: EJCB, 84(2), 123-135. doi:10.1016/j.ejcb.2004.12.013.

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Genre: Journal Article
Alternative Title : Eur. J. Cell Biol.

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123.pdf (Any fulltext), 496KB
 
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 Creators:
Roloff, Tim C.1, Author
Nuber, Ulrike A.2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Free keywords: Stem cells Epigenetics; Chromatin Histone modification DNA methylation Gene expression
 Abstract: Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control.

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Language(s): eng - English
 Dates: 2005-02-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 271582
DOI: 10.1016/j.ejcb.2004.12.013
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Title: European Journal of Cell Biology : EJCB
  Alternative Title : Eur. J. Cell Biol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 84 (2) Sequence Number: - Start / End Page: 123 - 135 Identifier: ISSN: 0070-2463