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  Functional genomics using high-throughput RNA interference

Vanhecke, D., & Janitz, M. (2005). Functional genomics using high-throughput RNA interference. Drug Discovery Today, 10(3), 205-212. doi:10.1016/S1359-6446(04)03352-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-86E7-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-86E8-6
Genre: Journal Article
Alternative Title : Drug Discov Today

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Vanhecke et al. - Drug Discov Today .pdf (Any fulltext), 244KB
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Vanhecke et al. - Drug Discov Today .pdf
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 Creators:
Vanhecke, Dominique1, Author
Janitz, Michal2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: Gene expression; Cell arrays; Transfection; Microarray
 Abstract: RNA interference (RNAi) describes the post-transcriptional silencing of gene expression that occurs in response to the introduction of double-stranded RNA into cells. Application of RNAi in experimental systems has provided a great leap forward in the elucidation of gene function. To facilitate large-scale functional genomics studies using RNAi, several high throughput approaches have been developed based on microarray or microwell assays. Recent establishment of large libraries of RNAi reagents combined with a variety of detection assays further opens the door for genome-wide screens of gene function in mammalian cells. The review provides a comprehensive overview on current RNA interference-based high throughput genomic technologies. The cell array- and microwell plate-based loss-of-function cell assays are presented.

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Language(s): eng - English
 Dates: 2005-02-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 276165
DOI: 10.1016/S1359-6446(04)03352-5
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Title: Drug Discovery Today
  Alternative Title : Drug Discov Today
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 10 (3) Sequence Number: - Start / End Page: 205 - 212 Identifier: ISSN: 1359-6446