English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos

Hofmann, M., Schuster-Gossler, K., Watabe-Rudolph, M., Aulehla, A., Herrmann, B. G., & Gossler, A. (2004). WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes and Development, 18(22), 2712-2717. doi:10.1101/gad.1248604.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-877D-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-877F-E
Genre: Journal Article
Alternative Title : Genes Dev

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Hofmann, Michael, Author
Schuster-Gossler, Karin, Author
Watabe-Rudolph, Masami, Author
Aulehla, Alexander, Author
Herrmann, Bernhard G.1, Author              
Gossler, Achim, Author
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

Content

show
hide
Free keywords: WNT signaling; Notch signaling; Dll1; somitogenesis; regulation
 Abstract: Notch signaling in the presomitic mesoderm (psm) is critical for somite formation and patterning. Here, we show that WNT signals regulate transcription of the Notch ligand Dll1 in the tailbud and psm. LEF/TCF factors cooperate with TBX6 to activate transcription from the Dll1 promoter in vitro. Mutating either T or LEF/TCF sites in the Dll1 promoter abolishes reporter gene expression in vitro as well as in the tail bud and psm of transgenic embryos. Our results indicate that WNT activity, in synergy with TBX6, regulates Dll1 transcription and thereby controls Notch activity, somite formation, and patterning.

Details

show
hide
Language(s): eng - English
 Dates: 2004-11-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 228898
DOI: 10.1101/gad.1248604
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genes and Development
  Alternative Title : Genes Dev
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 18 (22) Sequence Number: - Start / End Page: 2712 - 2717 Identifier: -