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  Annotating significant pairs of transcription factor binding sites in regulatory DNA

Rateitschak, K., Mueller, T., & Vingron, M. (2004). Annotating significant pairs of transcription factor binding sites in regulatory DNA. Special Issue: Ontology Workshop Tokyo 2003, 0040-0040.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-87E9-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-87EA-9
Genre: Journal Article
Alternative Title : In Silico Biol

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 Creators:
Rateitschak, Katja1, Author
Mueller, Tobias1, Author
Vingron, Martin2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: recognition of genes and regulatory elements, transcription factor binding site, score matrix.
 Abstract: In the presented work we search for transcription factor binding sites (BS) by including additional information about typical BS patterns. The new proposed score combines the ordinary profile score based on TRANSFAC-matrices together with a score based on pairs of BS. The latter score positively weights pairs of BS that tend to occur together in many regulatory DNA-sequences, in contrast to a random background model. The empirical BS pair frequencies result from our evaluation of a large dataset of orthologous genes.

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Language(s): eng - English
 Dates: 2004-08-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 229451
 Degree: -

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Title: Special Issue: Ontology Workshop Tokyo 2003
Source Genre: Issue
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 0040 - 0040 Identifier: -

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Title: In Silico Biology : an International Journal on Computational Molecular Biology
  Alternative Title : In Silico Biol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 4 Sequence Number: - Start / End Page: - Identifier: ISSN: 1386-6338