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  Regional and time-resolved mutation patterns of the human genome

Arndt, P. F., & Hwa, T. (2004). Regional and time-resolved mutation patterns of the human genome. Bioinformatics, 20(10), 1482-1485.

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 Urheber:
Arndt, Peter F.1, Autor           
Hwa, Terence, Autor
Affiliations:
1Evolutionary Genomics (Peter Arndt), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479638              

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Schlagwörter: -
 Zusammenfassung: Motivation: Substantial regional variations of substitutional processes have recently been reported from human/mouse comparisons. However, several features including the C + G dependence and the CpG-based transition effect remain obscure. Results: Utilizing the vast amount of transposable elements in the human genome, we performed detailed analysis of the substitutional and insertion/deletion patterns along the human lineage in a regional and time-resolved fashion. We observed a drastic increase in the CpG-based transition frequency at about the time of the mammalian radiation. We also observed clear regional biases of substitution patterns, most notably a bias to enrich the C+G content toward the telomeres.

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Sprache(n): eng - English
 Datum: 2004-07-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 226345
DOI: 10.1093/bioinformatics/bth105
 Art des Abschluß: -

Veranstaltung

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Titel: 18th GERMAN CONFERENCE ON BIOINFORMATICS 2003 (GCB’03)
Veranstaltungsort: Technische Universitaet Muenchen
Start-/Enddatum: 2003-10-12 - 2003-10-14

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Titel: Bioinformatics
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: 1482-1485 Band / Heft: 20 (10) Artikelnummer: - Start- / Endseite: 1482 - 1485 Identifikator: ISSN: 1460-2059