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  Regional and time-resolved mutation patterns of the human genome

Arndt, P. F., & Hwa, T. (2004). Regional and time-resolved mutation patterns of the human genome. Bioinformatics, 20(10), 1482-1485.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8816-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8817-E
Genre: Conference Paper

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 Creators:
Arndt, Peter F.1, Author              
Hwa, Terence, Author
Affiliations:
1Evolutionary Genomics (Peter Arndt), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479638              

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 Abstract: Motivation: Substantial regional variations of substitutional processes have recently been reported from human/mouse comparisons. However, several features including the C + G dependence and the CpG-based transition effect remain obscure. Results: Utilizing the vast amount of transposable elements in the human genome, we performed detailed analysis of the substitutional and insertion/deletion patterns along the human lineage in a regional and time-resolved fashion. We observed a drastic increase in the CpG-based transition frequency at about the time of the mammalian radiation. We also observed clear regional biases of substitution patterns, most notably a bias to enrich the C+G content toward the telomeres.

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Language(s): eng - English
 Dates: 2004-07-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 226345
DOI: 10.1093/bioinformatics/bth105
 Degree: -

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Title: 18th GERMAN CONFERENCE ON BIOINFORMATICS 2003 (GCB’03)
Place of Event: Technische Universitaet Muenchen
Start-/End Date: 2003-10-12 - 2003-10-14

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Title: Bioinformatics
Source Genre: Journal
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Publ. Info: -
Pages: 1482-1485 Volume / Issue: 20 (10) Sequence Number: - Start / End Page: 1482 - 1485 Identifier: ISSN: 1460-2059