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  Cohesin SMC1b is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination

Revenkova, E., Eijpe, M., Heyting, C., Hodges, C. A., Hunt, P. A., Liebe, B., et al. (2004). Cohesin SMC1b is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination. Nature Cell Biology, 6(6), 555-562. doi:10.1038/ncb1135.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-884D-5 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-884E-3
Genre: Zeitschriftenartikel
Alternativer Titel : Nat Cell Biol

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 Urheber:
Revenkova, Ekaterina, Autor
Eijpe, Maureen, Autor
Heyting, Christa, Autor
Hodges, Craig A., Autor
Hunt, Patricia A., Autor
Liebe, Bodo1, Autor
Scherthan, Harry2, Autor              
Jessberger, Rolf, Autor
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Zusammenfassung: Sister chromatid cohesion ensures the faithful segregation of chromosomes in mitosis and in both meiotic divisions1, 2, 3, 4. Meiosis-specific components of the cohesin complex, including the recently described SMC1 isoform SMC1beta5, were suggested to be required for meiotic sister chromatid cohesion and DNA recombination. Here we show that SMC1beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II. Prophase axial elements (AEs) are markedly shortened, chromatin extends further from the AEs, chromosome synapsis is incomplete, and sister chromatid cohesion in chromosome arms and at centromeres is lost prematurely. In addition, crossover-associated recombination foci are absent or reduced, and meiosis-specific perinuclear telomere arrangements are impaired. Thus, SMC1beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements.

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Sprache(n): eng - Englisch
 Datum: 2004-05-16
 Publikationsstatus: Im Druck publiziert
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 225138
DOI: 10.1038/ncb1135
 Art des Abschluß: -

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Titel: Nature Cell Biology
  Alternativer Titel : Nat Cell Biol
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 6 (6) Artikelnummer: - Start- / Endseite: 555 - 562 Identifikator: ISSN: 1465-7392