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  Three-dimensional structures of translating ribosomes by Cryo-EM

Gilbert, R. J. C., Fucini, P., Connell, S., Fuller, S. D., Nierhaus, K. H., Robinson, C. V., et al. (2004). Three-dimensional structures of translating ribosomes by Cryo-EM. Molecular Cell, 14(1), 57-66. doi:10.1016/S1097-2765(04)00163-7.

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Genre: Zeitschriftenartikel
Alternativer Titel : Mol Cell

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 Urheber:
Gilbert, Robert J. C., Autor
Fucini, Paola1, Autor           
Connell, Sean2, Autor           
Fuller, Stephen D., Autor
Nierhaus, Knud H.1, Autor           
Robinson, Carol V., Autor
Dobson, Christopher M., Autor
Stuart, David I., Autor
Affiliations:
1Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Zusammenfassung: Cryo-electron microscopy and image reconstruction techniques have been used to obtain three-dimensional maps for E. coli ribosomes stalled following translation of three representative proteins. Comparisons of these electron density maps, at resolutions of between 13 and 16 Å, with that of a nontranslating ribosome pinpoint specific structural differences in stalled ribosomes and identify additional material, including tRNAs and mRNA. In addition, the tunnel through the large subunit, the anticipated exit route of newly synthesized proteins, is partially occluded in all the stalled ribosome structures. This observation suggests that significant segments of the nascent polypeptide chains examined here could be located within an expanded tunnel, perhaps in a rudimentary globular conformation. Such behavior could be an important aspect of the folding of at least some proteins in the cellular environment.

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Sprache(n): eng - English
 Datum: 2004-04-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 224235
DOI: 10.1016/S1097-2765(04)00163-7
 Art des Abschluß: -

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Titel: Molecular Cell
  Alternativer Titel : Mol Cell
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 14 (1) Artikelnummer: - Start- / Endseite: 57 - 66 Identifikator: ISSN: 1097-2765