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  The genomic sequence and comparative analysis of the rat major histocompatibility complex

Hurt, P., Walter, L., Sudbrak, R., Klages, S., Mueller, I., Shiina, T., et al. (2004). The genomic sequence and comparative analysis of the rat major histocompatibility complex. Genome Research, 14(4), 631-639.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8884-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8885-3
Genre: Journal Article
Alternative Title : Genome Res

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 Creators:
Hurt, Peter1, Author
Walter, Lutz, Author
Sudbrak, Ralf2, Author              
Klages, Sven2, Author              
Mueller, Ines3, Author              
Shiina, Takashi, Author
Inoko, Hidetoshi, Author
Lehrach, Hans2, Author              
Guenther, Eberhard, Author
Reinhardt, Reinhard1, Author
Himmelbauer, Heinz2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
3Molecular Cytogenetics (Reinhard Ullmann), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479645              

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 Abstract: We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a segment of the rat genome and constitutes one of the largest contiguous sequences thus far for rodent genomes in general. The rat MHC is, next to the human MHC, the second mammalian MHC sequenced to completion. Our analysis has resulted in the identification of at least 220 genes located within the sequenced interval. Although gene content and order are well conserved in the class II and class III gene intervals as well as the framework gene regions, profound rat-specific features were encountered within the class I gene regions, in comparison to human and mouse. Class I region-associated differences were found both at the structural level, the number, and organization of class I genes and gene families, and, in a more global context, in the way that evolution worked to shape the present-day rat MHC. [Supplemental material is available online at www.genome.org. The nucleotide sequences reported in this work have been submitted to GenBank under accession nos. BX11170 and AL603724.]

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Language(s): eng - English
 Dates: 2004-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 174664
ISI: 000220629900015
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Title: Genome Research
  Alternative Title : Genome Res
Source Genre: Journal
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Pages: - Volume / Issue: 14 (4) Sequence Number: - Start / End Page: 631 - 639 Identifier: ISSN: 1088-9051