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  Genetics of congenital hand anomalies

Schwabe, G. C., & Mundlos, S. (2004). Genetics of congenital hand anomalies. Handchirurgie, Mikrochirurgie, Plastische Chirurgie, 36(2-3), 85-97. doi:10.1055/s-2004-817884.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-888A-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-888B-8
Genre: Journal Article
Alternative Title : Handchir Mikrochir Plast Chir

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 Creators:
Schwabe, Georg C.1, Author              
Mundlos, Stefan1, Author              
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Limb development; malformation; syndactyly; polydactyly; brachydactyly; genetics
 Abstract: Congenital limb malformations exhibit a wide spectrum of phenotypic manifestations and may occur as an isolated malformation and as part of a syndrome. They are individually rare, but due to their overall frequency and severity they are of clinical relevance. In recent years, increasing knowledge of the molecular basis of embryonic development has significantly enhanced our understanding of congenital limb malformations. In addition, genetic studies have revealed the molecular basis of an increasing number of conditions with primary or secondary limb involvement. The molecular findings have led to a regrouping of malformations in genetic terms. However, the establishment of precise genotype-phenotype correlations for limb malformations is difficult due to the high degree of phenotypic variability. We present an overview of congenital limb malformations based on an anatomic and genetic concept reflecting recent molecular and developmental insights.

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Language(s): eng - English
 Dates: 2004-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 228846
DOI: 10.1055/s-2004-817884
 Degree: -

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Title: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
  Alternative Title : Handchir Mikrochir Plast Chir
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 36 (2-3) Sequence Number: - Start / End Page: 85 - 97 Identifier: ISSN: 0722-1819