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  Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation

Singh, U., Fohn, L. E., Wakayama, T., Ohgane, J., Steinhoff, C., Lipkowitz, B., et al. (2004). Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation. Developmental Dynamics, 230(1), 149-164. doi:10.1002/dvdy.20024.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8893-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8894-1
Genre: Journal Article
Alternative Title : Dev Dyn

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 Creators:
Singh, Umashankar, Author
Fohn, Laurel E., Author
Wakayama, Teruhiko, Author
Ohgane, Jun, Author
Steinhoff, Christine1, Author              
Lipkowitz, Bettina2, Author              
Schulz, Ralph3, Author
Orth, Annie, Author
Ropers, Hans-Hilger4, Author              
Behringer, Richard R., Author
Tanaka, Satoshi, Author
Shiota, Kunio, Author
Yanagimachi, Ryuzo, Author
Nuber, Ulrike A.4, Author              
Fundele, Reinald4, Author              
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Familial Cognitive Disorders (Luciana Musante), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479644              
3Max Planck Society, ou_persistent13              
4Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Free keywords: IHPD • clones • Esx1 • placental hyperplasia • global gene expression
 Abstract: To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only one gene was shared between IHPD and Esx1 mutant, and cloned and Esx1 mutant placentas, respectively. These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy.

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Language(s): eng - English
 Dates: 2004-03-31
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 225235
DOI: 10.1002/dvdy.20024
 Degree: -

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Title: Developmental Dynamics
  Alternative Title : Dev Dyn
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 230 (1) Sequence Number: - Start / End Page: 149 - 164 Identifier: ISSN: 1058-8388