English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer

Himmelfarb, M., Klopocki, E., Grube, S., Staub, E., Klaman, I., Hinzmann, B., et al. (2004). ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. Cancer Letters: an International Journal Providing a Forum for Original and Pertinent Contributions in Cancer Research, 204(1), 69-77. doi:10.1016/j.canlet.2003.09.011.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Cancer Lett

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Himmelfarb, Marina, Author
Klopocki, Eva1, Author           
Grube, Susanne, Author
Staub, Eike2, Author
Klaman, Irina, Author
Hinzmann, Bernd, Author
Kristiansen, Glen, Author
Rosenthal, André, Author
Dürst, Matthias, Author
Dahl, Edgar, Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
2Max Planck Society, ou_persistent13              

Content

show
hide
Free keywords: Inter-small alpha, Greek-trypsin inhibitor; ITI heavy chain; Breast cancer; Tumor suppressor gene
 Abstract: The inter-small alpha, Greek-trypsin inhibitor (ITI) family constitutes a group of proteins built up from one light chain and a variable set of heavy chains. Originally identified as plasma protease inhibitors, recent data indicate that ITI plays a role in extracellular matrix (ECM) stabilization and in prevention of tumor metastasis. Here we describe cloning as well as phylogenetic and expression analysis of a novel member of the heavy chain gene family, ITIH5. ITIH5 contains the two domains conserved in all known ITIHs, the vault protein inter-alpha-trypsin (VIT) domain and a von Willebrand type A (vWA) domain. However, ITIH5 diverged early from a common ancestor of the other subfamilies. We found strong downregulation of ITIH5 expression in breast tumors by real-time PCR and RNA in situ hybridization. While normal breast epithelial cells clearly express ITIH5, expression is consistantly lost or strongly downregulated in invasive ductal carcinoma. ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development.

Details

show
hide
Language(s): eng - English
 Dates: 2004-02-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 226557
DOI: 10.1016/j.canlet.2003.09.011
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cancer Letters : an International Journal Providing a Forum for Original and Pertinent Contributions in Cancer Research
  Alternative Title : Cancer Lett
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 204 (1) Sequence Number: - Start / End Page: 69 - 77 Identifier: ISSN: 0304-3835