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  Serotonin regulates mammary gland development via an autocrine-paracrine loop

Matsuda, M., Imaoka, T., Vomachka, A. J., Gudelsky, G. A., Hou, Z., Mistry, M., et al. (2004). Serotonin regulates mammary gland development via an autocrine-paracrine loop. Developmental Cell, 6(2), 193-203. doi:10.1016/S1534-5807(04)00022-X.

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 Creators:
Matsuda, Manabu, Author
Imaoka, Tatsuhiko, Author
Vomachka, Archie J., Author
Gudelsky, Gary A., Author
Hou, Zhaoyuan, Author
Mistry, Meenakshi, Author
Bailey, Jason P., Author
Nieport, Kathryn M., Author
Walther, Diego J.1, Author              
Bader, Michael, Author
Horseman, Nelson D., Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: Mammary gland development is controlled by a dynamic interplay between endocrine hormones and locally produced factors. Biogenic monoamines (serotonin, dopamine, norepinephrine, and others) are an important class of bioregulatory molecules that have not been shown to participate in mammary development. Here we show that mammary glands stimulated by prolactin (PRL) express genes essential for serotonin biosynthesis (tryptophan hydroxylase [TPH] and aromatic amine decarboxylase). TPH mRNA was elevated during pregnancy and lactation, and serotonin was detected in the mammary epithelium and in milk. TPH was induced by PRL in mammosphere cultures and by milk stasis in nursing dams, suggesting that the gene is controlled by milk filling in the alveoli. Serotonin suppressed small beta, Greek-casein gene expression and caused shrinkage of mammary alveoli. Conversely, TPH1 gene disruption or antiserotonergic drugs resulted in enhanced secretory features and alveolar dilation. Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution.

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Language(s): eng - English
 Dates: 2004-02-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 224737
DOI: 10.1016/S1534-5807(04)00022-X
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Title: Developmental Cell
Source Genre: Journal
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Pages: - Volume / Issue: 6 (2) Sequence Number: - Start / End Page: 193 - 203 Identifier: ISSN: 1534-5807