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  Divergent genetic and epigenetic post-zygotic isolation mechanisms in Mus and Peromyscus

Zechner, U., Shi, W., Hemberger, M., Himmelbauer, H., Otto, S., Orth, A., et al. (2004). Divergent genetic and epigenetic post-zygotic isolation mechanisms in Mus and Peromyscus. Journal of Evolutionary Biology, 17(2), 453-460. doi:10.1046/j.1420-9101.2003.00656.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8904-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8905-E
Genre: Journal Article
Alternative Title : J Evol Biol

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 Creators:
Zechner, U.1, Author              
Shi, W., Author
Hemberger, M.2, Author
Himmelbauer, Heinz1, Author              
Otto, Sabine3, Author              
Orth, A., Author
Kalscheuer, Vera M.4, Author              
Fischer, Ute4, Author              
Elango, R., Author
Reis, A., Author
Vogel, W., Author
Ropers, Hans-Hilger5, Author              
Rüschendorf, F., Author
Fundele, Reinald5, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Max Planck Society, ou_persistent13              
3Familial Cognitive Disorders (Luciana Musante), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479644              
4Chromosome Rearrangements and Disease (Vera Kalscheuer), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479642              
5Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: Interspecific hybridization in the rodent genera Peromyscus and Mus results in abnormal placentation. In the Peromyscus interspecies hybrids, abnormal allelic interaction between an X-linked locus and the imprinted paternally expressed Peg3 locus was shown to cause the placental defects. In addition, loss-of-imprinting (LOI) of Peg3 was positively correlated with increased placental size. As in extreme cases this placental dysplasia constitutes a post-zygotic barrier against interspecies hybridization, this finding was the first direct proof that imprinted genes may be important in speciation and thus in evolution. In the Mus interspecies hybrids, a strong role of an X-linked locus in placental dysplasia has also been detected. However, here we show by backcross and allele specific expression analyses that neither LOI of Peg3 nor abnormal interactions between Peg3 and an X-linked locus are involved in generating placental dysplasia in Mus hybrids, although the placental phenotypes observed in the two genera seem to be identical. In contrast to this, another dysgenesis effect common to Peromyscus and Mus hybrids, altered foetal growth, is caused at least in part by the same X-chromosomal regions in both genera. These findings first underline the strong involvement of the X-chromosome in the genetics of speciation. Secondly, they indicate that disruption of epigenetic states, such as LOI, at specific loci may be involved in hybrid dysgenesis effects in one group, but not in another. Thus, we conclude that even in closely related groups divergent molecular mechanisms may be involved in the production of phenotypically similar post-zygotic barriers against hybridization.

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Language(s): eng - English
 Dates: 2004-01-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 226099
DOI: 10.1046/j.1420-9101.2003.00656.x
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Title: Journal of Evolutionary Biology
  Alternative Title : J Evol Biol
Source Genre: Journal
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Pages: - Volume / Issue: 17 (2) Sequence Number: - Start / End Page: 453 - 460 Identifier: ISSN: 1420-9101