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  Essential role for ADAM19 in cardiovascular morphogenesis

Zhou, H.-M., Weskamp, G., Chesneau, V., Sahin, U., Vortkamp, A., Horiuchi, K., et al. (2004). Essential role for ADAM19 in cardiovascular morphogenesis. Molecular and Cellular Biology, 24(1), 96-104. doi:10.1128/MCB.24.1.96-104.2004.

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Genre: Journal Article
Alternative Title : Mol Cell Biol

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 Creators:
Zhou, Hong-Ming, Author
Weskamp, Gisela, Author
Chesneau, Valérie, Author
Sahin, Umut, Author
Vortkamp, Andrea1, Author              
Horiuchi, Keisuke, Author
Chiusaroli, Riccardo, Author
Hahn, Rebecca, Author
Wilkes, David, Author
Fisher, Peter, Author
Baron, Roland, Author
Manova, Katia, Author
Basson, Craig T., Author
Hempstead, Barbara, Author
Blobel, Carl P., Author
Affiliations:
1Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

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 Abstract: Congenital heart disease is the most common form of human birth defects, yet much remains to be learned about its underlying causes. Here we report that mice lacking functional ADAM19 (mnemonic for a disintegrin and metalloprotease 19) exhibit severe defects in cardiac morphogenesis, including a ventricular septal defect (VSD), abnormal formation of the aortic and pulmonic valves, leading to valvular stenosis, and abnormalities of the cardiac vasculature. During mouse development, ADAM19 is highly expressed in the conotruncus and the endocardial cushion, structures that give rise to the affected heart valves and the membranous ventricular septum. ADAM19 is also highly expressed in osteoblast-like cells in the bone, yet it does not appear to be essential for bone growth and skeletal development. Most adam19-/- animals die perinatally, likely as a result of their cardiac defects. These findings raise the possibility that mutations in ADAM19 may contribute to human congenital heart valve and septal defects.

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Language(s): eng - English
 Dates: 2004-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 228635
DOI: 10.1128/MCB.24.1.96-104.2004
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Title: Molecular and Cellular Biology
  Alternative Title : Mol Cell Biol
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 24 (1) Sequence Number: - Start / End Page: 96 - 104 Identifier: ISSN: 0270-7306