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  Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase

Adelfalk, C., Kontou, M., Hirsch-Kauffmann, M., & Schweiger, M. (2003). Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase. FEBS Letters, 554(1-2), 55-58. doi:10.1016/S0014-5793(03)01088-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-896C-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-896D-4
Genre: Journal Article
Alternative Title : FEBS Lett.

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 Creators:
Adelfalk, Caroline1, Author              
Kontou, Maria, Author
Hirsch-Kauffmann, Monica, Author
Schweiger, Manfred, Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Free keywords: Werner's syndrome, WRN, poly-ADP ribosyl transferase, ADP-ribosylation
 Abstract: Werner’s syndrome is a rare disease of premature ageing. The WRN gene product defective in this disorder belongs to the RecQ helicase family and is thought to be involved in DNA metabolism. Another protein, which plays an important role in both DNA replication and repair, is the poly-ADP ribosyl transferase. Here we demonstrate an interaction of these two proteins resulting in ADP-ribosylation of the WRN protein. These results imply that WRN is involved in DNA replication and in DNA repair.

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Language(s): eng - English
 Dates: 2003-11-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Title: FEBS Letters
  Alternative Title : FEBS Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 554 (1-2) Sequence Number: - Start / End Page: 55 - 58 Identifier: ISSN: 0014-5793