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  A single amphioxus and sea urchin runt-gene suggests that runt-gene duplications occurred in early chordate evolution

Stricker, S., Poustka, A. J., Wiecha, U., Stiege, A., Hecht, J., Panopoulou, G., et al. (2003). A single amphioxus and sea urchin runt-gene suggests that runt-gene duplications occurred in early chordate evolution. Developmental and Comparative Immunology, 27(8), 673-684. doi:10.1016/S0145-305X(03)00037-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-89C2-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-89C3-F
Genre: Journal Article
Alternative Title : Dev. Comp. Immunol.

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 Creators:
Stricker, S.1, Author              
Poustka, A. J.2, Author              
Wiecha, U., Author
Stiege, A.1, Author              
Hecht, J.1, Author              
Panopoulou, G.2, Author              
Vilcinskas, A., Author
Mundlos, S.1, Author              
Seitz, V.1, Author              
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
2Evolution and Development (Albert Poustka), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479650              

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Free keywords: runt; amphioxus; sea urchin; cartilage; bone; hematopoiesis; gene duplication; chordates
 Abstract: Runt-homologous molecules are characterized by their DNA binding runt-domain which is highly conserved within bilaterians. The three mammalian runt-genes are master regulators in cartilage/bone formation and hematopoiesis. Historically these features evolved in Craniota and might have been promoted by runt-gene duplication events. The purpose of this study was therefore to investigate how many runt-genes exist in the stem species of chordates, by analyzing the number of runt-genes in what is likely to be the closest living relative of Craniota—amphioxus. To acquire further insight into the possible role of runt-genes in early chordate evolution we have determined the number of runt-genes in sea urchins and have analyzed the runt-expression pattern in this species. Our findings demonstrate the presence of a single runt-gene in amphioxus and sea urchin, which makes it highly likely that the stem species of chordates harbored only a single runt-gene. This suggests that runt-gene duplications occurred later in chordate phylogeny, and are possibly also associated with the evolution of features such as hematopoiesis, cartilage and bone development. In sea urchin embryos runt-expression involves cells of endodermal, mesodermal and ectodermal origin. This complex pattern of expression might reflect the multiple roles played by runt-genes in mammals. A strong runt-signal in the gastrointestinal tract of the sea urchin is in line with runt-expression in the intestine of nematodes and in the murine gastrointestinal tract, and seems to be one of the phylogenetically ancient runt-expression domains.

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Language(s): eng - English
 Dates: 2003-09
 Publication Status: Published in print
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Title: Developmental and Comparative Immunology
  Alternative Title : Dev. Comp. Immunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 27 (8) Sequence Number: - Start / End Page: 673 - 684 Identifier: ISSN: 0145-305X