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  DNA methylation in placentas of interspecies mouse hybrids

Schutt, S., Florl, A. R., Shi, W., Hemberger, M., Orth, A., Otto, S., et al. (2003). DNA methylation in placentas of interspecies mouse hybrids. Genetics, 165(1), 223-228.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-89C4-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-89C5-B
Genre: Journal Article
Alternative Title : Genetics

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 Creators:
Schutt, Sabine1, Author
Florl, Andrea R., Author
Shi, Wei1, Author
Hemberger, Myriam1, Author
Orth, Anni, Author
Otto, Sabine2, Author              
Schulz, Wolfgang A., Author
Fundele, Reinald H.3, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Familial Cognitive Disorders (Luciana Musante), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479644              
3Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: Interspecific hybridization in the genus Mus results in several hybrid dysgenesis effects, such as male sterility and X-linked placental dysplasia (IHPD). The genetic or molecular basis for the placental phenotypes is at present not clear. However, an extremely complex genetic system that has been hypothesized to be caused by major epigenetic changes on the X chromosome has been shown to be active. We have investigated DNA methylation of several single genes, Atrx, Esx1, Mecp2, Pem, Psx1, Vbp1, Pou3f4, and Cdx2, and, in addition, of LINE-1 and IAP repeat sequences, in placentas and tissues of fetal day 18 mouse interspecific hybrids. Our results show some tendency toward hypomethylation in the late gestation mouse placenta. However, no differential methylation was observed in hyper- and hypoplastic hybrid placentas when compared with normal-sized littermate placentas or intraspecific Mus musculus placentas of the same developmental stage. Thus, our results strongly suggest that generalized changes in methylation patterns do not occur in trophoblast cells of such hybrids.

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Language(s): eng - English
 Dates: 2003-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 194742
ISI: 000185618200017
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Title: Genetics
  Alternative Title : Genetics
Source Genre: Journal
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Pages: - Volume / Issue: 165 (1) Sequence Number: - Start / End Page: 223 - 228 Identifier: ISSN: 0016-6731