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  HC gp-39 gene is upregulated in glioblastomas

Shostak, K., Labunskyy, V., Dmitrenko, V., Malisheva, T., Shamayev, M., Rozumenko, V., et al. (2003). HC gp-39 gene is upregulated in glioblastomas. Cancer Letters, 198(2), 203-210. doi:10.1016/S0304-3835(03)00310-0.

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Genre: Journal Article
Alternative Title : Cancer Lett.

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 Creators:
Shostak, Katherina, Author
Labunskyy, Vyacheslav, Author
Dmitrenko, Vladimir, Author
Malisheva, Tatiana, Author
Shamayev, Michail, Author
Rozumenko, Vladimir, Author
Zozulya, Yuriy, Author
Zehetner, Guenther1, Author              
Kavsan, Vadym, Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: brain tumor, astrocytic gliomas, glioblastoma multiforme, electronic subtraction, differential expression, HC gp-39 gene
 Abstract: Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas.

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Language(s): eng - English
 Dates: 2003-08-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 194808
ISI: 000186363700010
DOI: 10.1016/S0304-3835(03)00310-0
 Degree: -

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Title: Cancer Letters
  Alternative Title : Cancer Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 198 (2) Sequence Number: - Start / End Page: 203 - 210 Identifier: ISSN: 0304-3835