English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Effects of sex chromosome dosage on placental size in mice

Ishikawa, H., Rattigan, A., Fundele, R., & Burgoyne, P. S. (2003). Effects of sex chromosome dosage on placental size in mice. Biology of Reproduction, 69(2), 483-488.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Biol. Reprod.

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Ishikawa, Hitoshi, Author
Rattigan, Aine, Author
Fundele, Reinald1, Author              
Burgoyne, Paul S., Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

Content

show
hide
Free keywords: developmental biology, embryo, placenta, pregnancy, trophoblast
 Abstract: Mice of the XO genotype with a paternally derived X chromosome (XpO) have placental hyperplasia in late pregnancy, although in early pregnancy the ectoplacental cone, a placental precursor, is smaller in XpO mice than in their XX sibs. This early size deficiency of the ectoplacental cone is apparently a consequence of Xp imprinting, because XmO embryos (with a maternally derived X chromosome) are unaffected. In the present study we sought to establish whether XpO placental hyperplasia in late pregnancy is also a consequence of Xp imprinting. Placental weight data were first collected from litters that included XpO or XmO fetuses and XX controls. Comparison of XO placentae with XX placentae showed that XpO and XmO placentae are hyperplastic. This finding suggested that the hyperplasia might be an X dosage effect, and this hypothesis was supported by the finding that XY male fetuses from the same crosses also had larger placentae than their XX sibs. Further analysis of a range of sex-chromosome variant genotypes, including XmYSry-negative females and XXSry transgenic males, showed that mouse fetuses with one X chromosome consistently had larger placentae than littermates with two X chromosomes, independent of their gonadal/androgen status.

Details

show
hide
Language(s): eng - English
 Dates: 2003-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 194746
ISI: 000184311100015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biology of Reproduction
  Alternative Title : Biol. Reprod.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 69 (2) Sequence Number: - Start / End Page: 483 - 488 Identifier: ISSN: 0006-3363