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  Structural insight into the antibiotic action of telithromycin against resistant mutants (vol 185, pg 4276, 2003)

Berisio, R., Harms, J., Schluenzen, F., Zarivach, R., Hansen, H. A. S., Fucini, P., et al. (2003). Structural insight into the antibiotic action of telithromycin against resistant mutants (vol 185, pg 4276, 2003). Journal of Bacteriology, 185(14), 4276-4279.

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Genre: Journal Article
Alternative Title : J. Bacteriol.

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 Creators:
Berisio, Rita1, Author           
Harms, Joerg2, Author
Schluenzen, Frank2, Author
Zarivach, Raz, Author
Hansen, Harly A. S.2, Author
Fucini, Paola1, Author           
Yonath, Ada, Author
Affiliations:
1Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              
2Max Planck Society, ou_persistent13              

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 Abstract: The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

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Language(s): eng - English
 Dates: 2003-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 173615
ISI: 000184692800044
 Degree: -

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Title: Journal of Bacteriology
  Alternative Title : J. Bacteriol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 185 (14) Sequence Number: - Start / End Page: 4276 - 4279 Identifier: ISSN: 0021-9193